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Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-Year Follow-up.

ZAFFAGNINI, S., et al. The American Journal of Sports Medicine, 2022, 03635465221115821.

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Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial.

ULIVI, M., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2022, 1-12.

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Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial.

GOBBI, A. et al. European Journal of Orthopaedic Surgery & Traumatology, 2022, 1-10.

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Minimally manipulated adipose derived mesenchymal stromal cells and osteoarthritis: A narrative review.

IBRAHIM, A. et al. Acta Bio Medica: Atenei Parmensis, 2022, 93.1.

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Characterization of Microfragmented Adipose Tissue Architecture, Mesenchymal Stromal Cell Content and Release of Paracrine Mediators.

RAGNI, E., et al. Journal of Clinical Medicine, 2022, 11.8: 2231.

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Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results: A Prospective Randomized Controlled Trial With 24-Month Follow-up.

RANDELLI, P. S., et al. The American Journal of Sports Medicine, 2022.

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Autologous Microfragmented Adipose Tissue for the Treatment of Knee Osteoarthritis: Real-World Data at Two Years Follow-Up.

SCREPIS D. et al. Journal of Clinical Medicine. 2022; 11(5):1268.

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Micronized lipoaspirate shows in vitro potential for wound healing.

BOSETTI, Michela, et al.  TERMIS-AM. 2019.

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Intraarticular injection of microfragmented adipose tissue plus arthroscopy in isolated primary patellofemoral osteoarthritis is clinically effective and not affected by age, BMI, or stage of osteoarthritis.

VASSO, M., et al. Journal of Orthopaedics and Traumatology, 2022, 23.1: 1-10.

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Autologous Micro-fragmented Adipose Tissue in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis. 2021.

WANG, J., et al.

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Long-term in vivo survival of 3D-bioprinted human lipoaspirate-derived adipose tissue: proteomic signature and cellular content.

SÄLJÖ, K., et al. Adipocyte, 2022, 11.1: 34-46.

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Adipose-Derived Stem Cells for Hip Osteoarthritis: A Promising Case Series

COCO V. et al. Annual of Case Reports & Reviews

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The Effect of Autologous Adipose Derived Mesenchymal Stem Cell Therapy in Chronic Patellar Tendinitis: A Case Study

RUSSO A. et al. Annual of Case Reports & Reviews

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Adipose-Derived Stem/Stromal Cells, Stromal Vascular Fraction, and Microfragmented Adipose Tissue.

RAGNI, E., et al. Orthobiologics. Springer, Cham, 2022. p. 47-61.

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A prospective study comparing leukocyte-poor platelet-rich plasma combined with hyaluronic acid and autologous microfragmented adipose tissue in patients with early knee osteoarthritis.

DALLO, I., et al. Stem Cells and Development, 2021.

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Health-related quality of life outcomes and Hospitalization length of stay after micro-fragmented autologous adipose tissue injection in minor amputations for diabetic foot ulceration (MiFrAADiF trial): results from a randomized controlled single-center clinical trial.

GENNAI, Stefano, et al.  International Angiology: a Journal of the International Union of Angiology, 2021.

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Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression

CASARI, G., et al. Stem Cell Research & Therapy, 2021, 12.1: 1-13.

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The use of intra-articular injection of autologous micro-fragmented adipose tissue as pain treatment for ankle osteoarthritis: a prospective not randomized clinical study

NATALI, S., et al. International Orthopaedics, 2021, 1-6.

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Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Years.

HEIDARI, N., et al. Stem Cells International, 2021, 2021.

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Autologous Micro-Fragmented Adipose Tissue (MFAT) to Treat Symptomatic Knee Osteoarthritis: Early Outcomes of a Consecutive Case Series

VAN GENECHTEN, W., et al. Journal of Clinical Medicine, 2021, 10.11: 2231.

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A pilot study to evaluate micro-fragmented adipose tissue injection under ultrasound guidance for the treatment of refractory rotator cuff disease in wheelchair users with spinal cord injury.

HOGABOOM, N., et al. The Journal of Spinal Cord Medicine, 2021, 1-10.

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Autologous, micro-fragmented adipose tissue as a treatment for chronic shoulder pain in a wheelchair using individual with spinal cord injury: a case report.

CHERIAN, C., et al. Spinal cord series and cases, 2019, 5.1: 1-5.

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Chronic prosthesis-related residual limb ulcer treated with autologous micro-fragmented adipose tissue

COPELAND, R. et al. Regenerative Therapy, 2021, 18: 21-23.

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Temporomandibular joint arthrocentesis and microfragmented adipose tissue injection for the treatment of internal derangement and osteoarthritis: a randomized clinical trial

SEMBRONIO, S., et al. Journal of Oral and Maxillofacial Surgery, 2021.

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Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies’ Guidelines

PRIMORAC et al. Pharmaceuticals 2021, 14, 205.

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Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis: a multi-centric, international study

GOBBI A. et al. International Orthopaedics, March 2021

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Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years

BORG, T., et al. Stem Cells International, 2021, 2021.

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Open-Wedge High Tibial Osteotomy Associated With Lipogems® Intra-Articular Injection For The Treatment Of Varus Knee Osteoarthritis-Retrospective Study

MAGNANELLI, S., et al. Acta Bio-medica: Atenei Parmensis, 2020, 91.14-S: e2020022-e2020022.

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Autologous micro-fragmented adipose tissue as stem cell-based natural scaffold for cartilage defect repair.

XU, T., et al. Cell transplantation, 2019, 28.12: 1709-1720.

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Outcomes after Micronized Fat Adipose Transfer for Glenohumeral Joint Arthritis and Rotator Cuff Pathology: a Case Series of 18 Shoulders.

ROBINSON, D. M., et al. Muscles, Ligaments & Tendons Journal (MLTJ), 2020, 10.3.

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Functional outcomes following microfragmented adipose tissue versus bone marrow aspirate concentrate injections for symptomatic knee osteoarthritis.

MAUTNER, K., et al. Stem cells translational medicine, 2019, 8.11: 1149-1156.

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Clinical evaluation of micro-fragmented adipose tissue as a treatment option for patients with meniscus tears with osteoarthritis: a prospective pilot study.

MALANGA, G. A., et al. International Orthopaedics, 2021, 45.2: 473-480.

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Microfragmented adipose injections in the treatment of knee osteoarthritis

MALANGA, G. A., et al. Journal of Clinical Orthopaedics & Trauma, 2019, 10.1: 46-48.

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Chemical Profile and Clinical Efficacy of Micro-Fragmented Adipose Tissue in the Treatment of Knee Osteoarthritis.

HABERL, J.; MALANGA, G.; HOGABOOM, N. Biologic Orthopedics Journal, 2020, 2.1.

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Minimally manipulated mesenchymal stem cells for the treatment of knee osteoarthritis: a systematic review of clinical evidence.

DI MATTEO, B., et al. Stem cells international, 2019, 2019.

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Autologous, micro-fragmented adipose tissue as a treatment for chronic shoulder pain in a wheelchair using individual with spinal cord injury: a case report.

CHERIAN, C., et al. Spinal cord series and cases, 2019, 5.1: 1-5.

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Mesenchymal Stromal Cell Therapy in the Management of Perianal Fistulas in Crohn’s Disease: An Up-To-Date Review.

GALLO, G., et al. Medicina, 2020, 56.11: 563.

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Safety and Feasibility of Autologous Micro-Fragmented Adipose Tissue Injections for the Treatment of Vaginal Atrophy, Vulvovaginal Dystrophy, and Stress Urinary Incontinence: An Observational Case Series.

STARK, L., et al. UROLOGY, 2020.

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Open-Wedge High Tibial Osteotomy Associated With Lipogems® Intra-Articular Injection For The Treatment Of Varus Knee Osteoarthritis-Retrospective Study

MAGNANELLI, S., et al. Acta Bio-medica: Atenei Parmensis, 2020, 91.14-S: e2020022-e2020022.

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Micro-fragmentation is a valid alternative to cell expansion and enzymatic digestion of adipose tissue for the treatment of knee osteoarthritis: a comparative preclinical study

FILARDO, G., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 1-9.

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Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis

VINET-JONES, H.; F DARR, K. Regenerative Medicine, 2020, 0.

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The use of mesenchimal stem cell in orthopedics: indications and limits

FERRACINI, R., et al. Giornale Italiano di Ortopedia e Traumatologia, 2020, 46: 3-8.

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Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months.

HEIDARI, N., et al. Stem Cells International, 2020

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Autologous microfragmented adipose tissue reduces inflammatory and catabolic markers in supraspinatus tendon cells derived from patients affected by rotator cuff tears.

VIGANÒ, M., et al. International Orthopaedics, 2020, 1-8.

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The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study

RUSSO, A.; COCO, V.; ZAFFAGNINI, S., Journal of Surgical Case Reports, 2020, 2020.8: rjaa274.

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A new treatment of genito-urinary post-menopausal atrophy with autologous micro-fragmented fat tissue: a thirty-six months follow up case series

CASAROTTI, G.; TREMOLADA, C., European Review for Medical and Pharmacological Sciences, 2020, 24: 7420-7426.

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Micro-fragmented Adipose Tissue Transplantation (MATT) for the treatment of acetabular delamination. A two years follow up comparison study with microfractures.

IVONE, A., et al. Acta bio-medica: Atenei Parmensis, 2019, 90.12-S: 69.

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A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

BORIĆ, Igor, et al. Genes, 2019, 10.12: 1051.

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Treatment of osteoarthritis with autologous and microfragmented adipose tissue

BARFOD, K. W.; BLØND, L. Danish medical journal, 2019, 66.10.

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Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences

LOPA, S., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2019, 27.6: 2003-2020.

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Rectal advancement flap plus adipose lipofilling (RAFAL) for the treatment of rectourethral fistulas after radical prostatectomy

ZUIN, M., et al. , Techniques in coloproctology; 2019, 1-5.

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Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: a randomized controlled single-center clinical trial (MiFrAADiF)

LONARDI, R., et al. Stem cell research & therapy, 2019; 10.1: 223.

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Micro-fragmented stromal-vascular fraction plus microfractures provides better clinical results than microfractures alone in symptomatic focal chondral lesions of the knee

BISICCHIA, S., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2019; 1-9.

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Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Treatment and Its Lipoaspirate Counterpart

POLANCEC, D., et al. Genes, 2019; 10(6): 474.

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Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study

HUDETZ, D., et al. Croatian medical journal, 2019; 60(3): 227.

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Refractory Complex Crohn’s Perianal Fistulas: A Role for Autologous Microfragmented Adipose Tissue Injection

LAURETI, S., et al. Inflammatory Bowel Diseases, 2019.

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Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue

NAVA, S., et al. Stem Cells International 2019

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Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results

DALL’OCA, C., et al.  Acta Bio Medica Atenei Parmensis, 2019; 90.1-S: 75-80.

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Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response

PANNI, A. S., et al.  International orthopaedics, 2018, 1-7.

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Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3 year follow-up

RUSSO, A., et al. Journal of Experimental Orthopaedics, 2018; 5:52.

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Microfragmented adipose injections in the treatment of knee osteoarthritis

MALANGA, G. A., BEMANIAN, S.  Journal of Clinical Orthopaedics & Trauma, 2018.

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Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees

PANCHAL, J., et al. The American Journal of Orthopedics, 2018.

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A New Nonenzymatic Method and Device to Obtain a Fat Tissue Derivative Highly Enriched in Pericyte-Like Elements by Mild Mechanical Forces From Human Lipoaspirates

BIANCHI, F., et al. Cell transplantation, 2013; 22(11):2063-2077.

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Characteristics and Properties of Mesenchymal Stem Cells Derived From Microfragmented Adipose Tissue

CARELLI, S., et al. Cell transplantation, 2015; 24(7):1233-1252.

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Lipogems, a New Modality of Fat Tissue Handling to Enhance Tissue Repair in Chronic Hind Limb Ischemia

TASSINARI, R., et al. CellR4, 2014; 2:e1289.

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Micro-fragmented fat injection reduces sepsis induced acute inflammatory response in a mouse model

BOUGLÉ, A., et al.  British Journal of Anaesthesia, 2018.

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Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells

CESERANI, V., et al. Vascular cell, 2016; 8:3.

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Differences in exosome content of human adipose tissue processed by non-enzymatic and enzymaticmethods

GARCÍA-CONTRERAS, M., et al. CellR4, 2015; 3(1):e1423.

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Human Lipoaspirate as Autologous Injectable Active Scaffold for One-Step Repair of Cartilage Defects

BOSETTI, M., et al. Cell transplantation, 2016; 25(6):1043-1056.

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Lipogems Product Treatment Increases the Proliferation Rate of Human Tendon Stem Cells without Affecting Their Stemness and Differentiation Capability

RANDELLI, P., et al. Stem cells international, 2016.

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Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development

TREMOLADA, C., et al. Current stem cell reports, 2016; 2(3):304-312.

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Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors 

PAOLELLA, F., et al. Journal of cellular physiology, 2018; 1-12.

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Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction 

VEZZANI, B., et al. Stem cells translational medicine, 2018.

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Metabolomic changes in human adipose tissue derived products following non-enzymatic microfacturing

GARCIA-CONTRERAS, M., et al. European review for medical and pharmacological sciences, 2018; 22(10):3249-3260.

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Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes

ZEIRA, O., et al. Stem cells translational medicine, 2018; 0(0):1–10

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Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis

CATTANEO, G., et al. BMC musculoskeletal disorders, 2018; 19(1):176.

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Refractory Shoulder Pain with Osteoarthritis, and Rotator Cuff Tear, Treated With Micro-Fragmented Adipose Tissue

STRIANO, R.D., et al. Orthop Spine Sports Med, 2018; 2(1):014

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Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

D’AMBROSI, R., et al. JoVE (Journal of Visualized Experiments), 2018; 131:e56395-e56395.

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Non-Responding Knee Pain with Osteoarthritis, Meniscus and Ligament Tears Treated with Ultrasound Guided Autologous, Micro-Fragmented and Minimally Manipulated Adipose Tissue

STRIANO, R.D., et al. Open Journal of Regenerative Medicine, 2017; 6:17-26.

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Non-Responsive Knee Pain with Osteoarthritis and Concurrent Meniscal Disease Treated With Autologous Micro-Fragmented Adipose Tissue Under Continuous Ultrasound Guidance

STRIANO, R.D., et al. CellR4, 2015; 3(5):e1690.

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Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis

RUSSO, A., et al. Journal of Experimental Orthopaedics, 2017; 4:33.

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The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis

HUDETZ, D., et al. Genes, 2017; 8(10):270.

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Injection of autologous micro-fragmented adipose tissue for the treatment of post-traumatic degenerative lesion of knee cartilage: a case report

FRANCESCHINI, M., et al. CellR4, 2016; 4(1):e1768.

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Micro Fractured and Purified Adipose Tissue Graft (Lipogems®) Can Improve the Orthognathic Surgery Outcomes Both Aesthetically and in Postoperative Healing

RAFFAINI, M., et al. CellR4, 2014; 2(4):e1118.

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Microfractured Lipoaspirate May Help Oral Bone and Soft Tissue Regeneration: a Case Report

BENZI, R., et al. CellR4, 2015; 3(3):e1583.

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Transnasal endoscopic microfractured fat injection in glottic insufficiency

SAIBENE, A. M., et al. B-ENT, 2015; 11(3):229-34.

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Low back pain treated with disc decompression and autologous micro-fragmented adipose tissue: a case report

GROSSI, P., et al. CellR4, 2016; 1772:4.

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Menopause: new frontiers in the treatment of urogenital atrophy

CASAROTTI, G.A., et al. European review for medical and pharmacological sciences, 2018; 22:567-574.

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Autologous adipose tissue graft in the vulva in severe vulvar lichen sclerosus atrophicus: clinical case

DE VITA, D., et al. Italian Journal of Gynaecology & Obstetrics, 2016; 28(5).

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Microfractured and Purified Adipose Tissue (Lipogems™ system) Injections for Treatment of Atrophic Vaginitis

FANTASIA, J., et al. The Journal of Urology, 2016, 3.7:1073.

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Intersphincteric anal lipofilling with micro-fragmented fat tissue for the treatment of faecal incontinence: preliminary results of three patients

CESTARO, G., et al. Videosurgery and Other Miniinvasive Techniques, 2015; 10(2):337–341.

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Recovery of Function in Anal Incontinence After Micro-Fragmented Fat Graft (Lipogems®) Injection: Two Years Follow Up of the First 5 Cases

GIORI, A., et al. CellR4, 2015; 3(2):e1544.

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Micro‑fragmented adipose tissue injection for the treatment of complex anal fistula: a pilot study accessing safety and feasibility

NALDINI, G., et al. Techniques in coloproctology, 2018; 22(2):107-113.

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