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A Worldwide Analysis of Adipose-Derived Stem Cells and Stromal Vascular Fraction in Orthopedics: Current Evidence and Applications.
OSSENDORFF, R., et al. Journal of Clinical Medicine, 2023, 12.14: 4719.
Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review.
ENTESSARI, M., et al. Regenerative Medicine, 2023, 0.
Efficacy and Duration of Intra-Articular Autologous Micro-Fragmented Adipose Tissue in Athletes with Ankle Osteoarthritis: A 36-Month Follow-Up Study.
IACONO, V., et al. Applied Sciences, 2023, 13.15: 8983.
Efficacy and Long-Term Outcomes of Intra-Articular Autologous Micro-Fragmented Adipose Tissue in Individuals with Glenohumeral Osteoarthritis: A 36-Month Follow-Up Study.
NATALI, S., et al. Journal of Personalized Medicine, 2023, 13.9: 1309.
Orthobiologic injections for treating degenerative meniscus lesions: a matter of facts? Ten years of clinical experience in a systematic review.
CONTE, P., et al. Journal of Cartilage & Joint Preservation, 2023, 100104.
An observational study evaluating the efficacy of microfragmented adipose tissue in the treatment of osteoarthritis.
FAN, F., et al. Regenerative Medicine, 2022, 0.
Echo-Assisted Intersphincteric 14 Autologous Microfragmented Adipose Tissue Injection to Control Fecal Incontinence in Children
PARENTE, G., et al. Ano-Rectal Endosonography and Manometry in Paediatrics. Springer, Cham, 2022. p. 141-149.
Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up.
NATALI, S., et al. International Orthopaedics, 2022, 1-6.
Autologous micro-fragmented adipose tissue associated with arthroscopy in moderate–severe knee osteoarthritis: outcome at two year follow-up.
GIORGINI, A., et al. BMC Musculoskeletal Disorders, 2022, 23.1: 1-9.
Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue.
FERRACINI, R., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2022, 1-10.
Microfragmented Adipose Tissue Versus Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis: A Prospective Randomized Controlled Trial at 2-Year Follow-up.
ZAFFAGNINI, S., et al. The American Journal of Sports Medicine, 2022, 03635465221115821.
Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial.
ULIVI, M., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2022, 1-12.
Autologous microfragmented adipose tissue and leukocyte-poor platelet-rich plasma combined with hyaluronic acid show comparable clinical outcomes for symptomatic early knee osteoarthritis over a two-year follow-up period: a prospective randomized clinical trial.
GOBBI, A. et al. European Journal of Orthopaedic Surgery & Traumatology, 2022, 1-10.
Minimally manipulated adipose derived mesenchymal stromal cells and osteoarthritis: A narrative review.
IBRAHIM, A. et al. Acta Bio Medica: Atenei Parmensis, 2022, 93.1.
Characterization of Microfragmented Adipose Tissue Architecture, Mesenchymal Stromal Cell Content and Release of Paracrine Mediators.
RAGNI, E., et al. Journal of Clinical Medicine, 2022, 11.8: 2231.
Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results: A Prospective Randomized Controlled Trial With 24-Month Follow-up.
RANDELLI, P. S., et al. The American Journal of Sports Medicine, 2022.
Autologous Microfragmented Adipose Tissue for the Treatment of Knee Osteoarthritis: Real-World Data at Two Years Follow-Up.
SCREPIS D. et al. Journal of Clinical Medicine. 2022; 11(5):1268.
Micronized lipoaspirate shows in vitro potential for wound healing.
BOSETTI, Michela, et al. TERMIS-AM. 2019.
Intraarticular injection of microfragmented adipose tissue plus arthroscopy in isolated primary patellofemoral osteoarthritis is clinically effective and not affected by age, BMI, or stage of osteoarthritis.
VASSO, M., et al. Journal of Orthopaedics and Traumatology, 2022, 23.1: 1-10.
Autologous Micro-fragmented Adipose Tissue in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis. 2021.
WANG, J., et al.
Long-term in vivo survival of 3D-bioprinted human lipoaspirate-derived adipose tissue: proteomic signature and cellular content.
SÄLJÖ, K., et al. Adipocyte, 2022, 11.1: 34-46.
Adipose-Derived Stem Cells for Hip Osteoarthritis: A Promising Case Series
COCO V. et al. Annual of Case Reports & Reviews
The Effect of Autologous Adipose Derived Mesenchymal Stem Cell Therapy in Chronic Patellar Tendinitis: A Case Study
RUSSO A. et al. Annual of Case Reports & Reviews
Adipose-Derived Stem/Stromal Cells, Stromal Vascular Fraction, and Microfragmented Adipose Tissue.
RAGNI, E., et al. Orthobiologics. Springer, Cham, 2022. p. 47-61.
A prospective study comparing leukocyte-poor platelet-rich plasma combined with hyaluronic acid and autologous microfragmented adipose tissue in patients with early knee osteoarthritis.
DALLO, I., et al. Stem Cells and Development, 2021.
Health-related quality of life outcomes and Hospitalization length of stay after micro-fragmented autologous adipose tissue injection in minor amputations for diabetic foot ulceration (MiFrAADiF trial): results from a randomized controlled single-center clinical trial.
GENNAI, Stefano, et al. International Angiology: a Journal of the International Union of Angiology, 2021.
Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression
CASARI, G., et al. Stem Cell Research & Therapy, 2021, 12.1: 1-13.
The use of intra-articular injection of autologous micro-fragmented adipose tissue as pain treatment for ankle osteoarthritis: a prospective not randomized clinical study
NATALI, S., et al. International Orthopaedics, 2021, 1-6.
Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Years.
HEIDARI, N., et al. Stem Cells International, 2021, 2021.
Autologous Micro-Fragmented Adipose Tissue (MFAT) to Treat Symptomatic Knee Osteoarthritis: Early Outcomes of a Consecutive Case Series
VAN GENECHTEN, W., et al. Journal of Clinical Medicine, 2021, 10.11: 2231.
A pilot study to evaluate micro-fragmented adipose tissue injection under ultrasound guidance for the treatment of refractory rotator cuff disease in wheelchair users with spinal cord injury.
HOGABOOM, N., et al. The Journal of Spinal Cord Medicine, 2021, 1-10.
Autologous, micro-fragmented adipose tissue as a treatment for chronic shoulder pain in a wheelchair using individual with spinal cord injury: a case report.
CHERIAN, C., et al. Spinal cord series and cases, 2019, 5.1: 1-5.
Chronic prosthesis-related residual limb ulcer treated with autologous micro-fragmented adipose tissue
COPELAND, R. et al. Regenerative Therapy, 2021, 18: 21-23.
Temporomandibular joint arthrocentesis and microfragmented adipose tissue injection for the treatment of internal derangement and osteoarthritis: a randomized clinical trial
SEMBRONIO, S., et al. Journal of Oral and Maxillofacial Surgery, 2021.
Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies’ Guidelines
PRIMORAC et al. Pharmaceuticals 2021, 14, 205.
Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis: a multi-centric, international study
GOBBI A. et al. International Orthopaedics, March 2021
Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years
BORG, T., et al. Stem Cells International, 2021, 2021.
Open-Wedge High Tibial Osteotomy Associated With Lipogems® Intra-Articular Injection For The Treatment Of Varus Knee Osteoarthritis-Retrospective Study
MAGNANELLI, S., et al. Acta Bio-medica: Atenei Parmensis, 2020, 91.14-S: e2020022-e2020022.
Autologous micro-fragmented adipose tissue as stem cell-based natural scaffold for cartilage defect repair.
XU, T., et al. Cell transplantation, 2019, 28.12: 1709-1720.
Outcomes after Micronized Fat Adipose Transfer for Glenohumeral Joint Arthritis and Rotator Cuff Pathology: a Case Series of 18 Shoulders.
ROBINSON, D. M., et al. Muscles, Ligaments & Tendons Journal (MLTJ), 2020, 10.3.
Functional outcomes following microfragmented adipose tissue versus bone marrow aspirate concentrate injections for symptomatic knee osteoarthritis.
MAUTNER, K., et al. Stem cells translational medicine, 2019, 8.11: 1149-1156.
Clinical evaluation of micro-fragmented adipose tissue as a treatment option for patients with meniscus tears with osteoarthritis: a prospective pilot study.
MALANGA, G. A., et al. International Orthopaedics, 2021, 45.2: 473-480.
Microfragmented adipose injections in the treatment of knee osteoarthritis
MALANGA, G. A., et al. Journal of Clinical Orthopaedics & Trauma, 2019, 10.1: 46-48.
Chemical Profile and Clinical Efficacy of Micro-Fragmented Adipose Tissue in the Treatment of Knee Osteoarthritis.
HABERL, J.; MALANGA, G.; HOGABOOM, N. Biologic Orthopedics Journal, 2020, 2.1.
Minimally manipulated mesenchymal stem cells for the treatment of knee osteoarthritis: a systematic review of clinical evidence.
DI MATTEO, B., et al. Stem cells international, 2019, 2019.
Autologous, micro-fragmented adipose tissue as a treatment for chronic shoulder pain in a wheelchair using individual with spinal cord injury: a case report.
CHERIAN, C., et al. Spinal cord series and cases, 2019, 5.1: 1-5.
Mesenchymal Stromal Cell Therapy in the Management of Perianal Fistulas in Crohn’s Disease: An Up-To-Date Review.
GALLO, G., et al. Medicina, 2020, 56.11: 563.
Safety and Feasibility of Autologous Micro-Fragmented Adipose Tissue Injections for the Treatment of Vaginal Atrophy, Vulvovaginal Dystrophy, and Stress Urinary Incontinence: An Observational Case Series.
STARK, L., et al. UROLOGY, 2020.
Open-Wedge High Tibial Osteotomy Associated With Lipogems® Intra-Articular Injection For The Treatment Of Varus Knee Osteoarthritis-Retrospective Study
MAGNANELLI, S., et al. Acta Bio-medica: Atenei Parmensis, 2020, 91.14-S: e2020022-e2020022.
Micro-fragmentation is a valid alternative to cell expansion and enzymatic digestion of adipose tissue for the treatment of knee osteoarthritis: a comparative preclinical study
FILARDO, G., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 1-9.
Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis
VINET-JONES, H.; F DARR, K. Regenerative Medicine, 2020, 0.
The use of mesenchimal stem cell in orthopedics: indications and limits
FERRACINI, R., et al. Giornale Italiano di Ortopedia e Traumatologia, 2020, 46: 3-8.
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months.
HEIDARI, N., et al. Stem Cells International, 2020
Autologous microfragmented adipose tissue reduces inflammatory and catabolic markers in supraspinatus tendon cells derived from patients affected by rotator cuff tears.
VIGANÒ, M., et al. International Orthopaedics, 2020, 1-8.
The effect of autologous adipose derived mesenchymal stem cell therapy on juvenile osteochondritis dissecans of the patella: a case study
RUSSO, A.; COCO, V.; ZAFFAGNINI, S., Journal of Surgical Case Reports, 2020, 2020.8: rjaa274.
A new treatment of genito-urinary post-menopausal atrophy with autologous micro-fragmented fat tissue: a thirty-six months follow up case series
CASAROTTI, G.; TREMOLADA, C., European Review for Medical and Pharmacological Sciences, 2020, 24: 7420-7426.
Micro-fragmented Adipose Tissue Transplantation (MATT) for the treatment of acetabular delamination. A two years follow up comparison study with microfractures.
IVONE, A., et al. Acta bio-medica: Atenei Parmensis, 2019, 90.12-S: 69.
A 24-Month Follow-Up Study of the Effect of Intra-Articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis
BORIĆ, Igor, et al. Genes, 2019, 10.12: 1051.
Treatment of osteoarthritis with autologous and microfragmented adipose tissue
BARFOD, K. W.; BLØND, L. Danish medical journal, 2019, 66.10.
Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences
LOPA, S., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2019, 27.6: 2003-2020.
Rectal advancement flap plus adipose lipofilling (RAFAL) for the treatment of rectourethral fistulas after radical prostatectomy
ZUIN, M., et al. , Techniques in coloproctology; 2019, 1-5.
Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: a randomized controlled single-center clinical trial (MiFrAADiF)
LONARDI, R., et al. Stem cell research & therapy, 2019; 10.1: 223.
Micro-fragmented stromal-vascular fraction plus microfractures provides better clinical results than microfractures alone in symptomatic focal chondral lesions of the knee
BISICCHIA, S., et al. Knee Surgery, Sports Traumatology, Arthroscopy, 2019; 1-9.
Immunophenotyping of a Stromal Vascular Fraction from Microfragmented Lipoaspirate Used in Osteoarthritis Cartilage Treatment and Its Lipoaspirate Counterpart
POLANCEC, D., et al. Genes, 2019; 10(6): 474.
Early results of intra-articular micro-fragmented lipoaspirate treatment in patients with late stages knee osteoarthritis: a prospective study
HUDETZ, D., et al. Croatian medical journal, 2019; 60(3): 227.
Refractory Complex Crohn’s Perianal Fistulas: A Role for Autologous Microfragmented Adipose Tissue Injection
LAURETI, S., et al. Inflammatory Bowel Diseases, 2019.
Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue
NAVA, S., et al. Stem Cells International 2019
Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results
DALL’OCA, C., et al. Acta Bio Medica Atenei Parmensis, 2019; 90.1-S: 75-80.
Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response
PANNI, A. S., et al. International orthopaedics, 2018, 1-7.
Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3 year follow-up
RUSSO, A., et al. Journal of Experimental Orthopaedics, 2018; 5:52.
Microfragmented adipose injections in the treatment of knee osteoarthritis
MALANGA, G. A., BEMANIAN, S. Journal of Clinical Orthopaedics & Trauma, 2018.
Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees
PANCHAL, J., et al. The American Journal of Orthopedics, 2018.
A New Nonenzymatic Method and Device to Obtain a Fat Tissue Derivative Highly Enriched in Pericyte-Like Elements by Mild Mechanical Forces From Human Lipoaspirates
BIANCHI, F., et al. Cell transplantation, 2013; 22(11):2063-2077.
Characteristics and Properties of Mesenchymal Stem Cells Derived From Microfragmented Adipose Tissue
CARELLI, S., et al. Cell transplantation, 2015; 24(7):1233-1252.
Lipogems, a New Modality of Fat Tissue Handling to Enhance Tissue Repair in Chronic Hind Limb Ischemia
TASSINARI, R., et al. CellR4, 2014; 2:e1289.
Micro-fragmented fat injection reduces sepsis induced acute inflammatory response in a mouse model
BOUGLÉ, A., et al. British Journal of Anaesthesia, 2018.
Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells
CESERANI, V., et al. Vascular cell, 2016; 8:3.
Differences in exosome content of human adipose tissue processed by non-enzymatic and enzymaticmethods
GARCÍA-CONTRERAS, M., et al. CellR4, 2015; 3(1):e1423.
Human Lipoaspirate as Autologous Injectable Active Scaffold for One-Step Repair of Cartilage Defects
BOSETTI, M., et al. Cell transplantation, 2016; 25(6):1043-1056.
Lipogems Product Treatment Increases the Proliferation Rate of Human Tendon Stem Cells without Affecting Their Stemness and Differentiation Capability
RANDELLI, P., et al. Stem cells international, 2016.
Adipose Tissue and Mesenchymal Stem Cells: State of the Art and Lipogems® Technology Development
TREMOLADA, C., et al. Current stem cell reports, 2016; 2(3):304-312.
Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors
PAOLELLA, F., et al. Journal of cellular physiology, 2018; 1-12.
Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction
VEZZANI, B., et al. Stem cells translational medicine, 2018.
Metabolomic changes in human adipose tissue derived products following non-enzymatic microfacturing
GARCIA-CONTRERAS, M., et al. European review for medical and pharmacological sciences, 2018; 22(10):3249-3260.
Use of adipose tissue stem cells in chronic skin lesions: clinical experience
MOFFA, F., et al. Italian Journal of Wound Care, 2018; 2(2):37-39
Intra-Articular Administration of Autologous Micro-Fragmented Adipose Tissue in Dogs with Spontaneous Osteoarthritis: Safety, Feasibility, and Clinical Outcomes
ZEIRA, O., et al. Stem cells translational medicine, 2018; 0(0):1–10
Micro-fragmented adipose tissue injection associated with arthroscopic procedures in patients with symptomatic knee osteoarthritis
CATTANEO, G., et al. BMC musculoskeletal disorders, 2018; 19(1):176.
Refractory Shoulder Pain with Osteoarthritis, and Rotator Cuff Tear, Treated With Micro-Fragmented Adipose Tissue
STRIANO, R.D., et al. Orthop Spine Sports Med, 2018; 2(1):014
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
D’AMBROSI, R., et al. JoVE (Journal of Visualized Experiments), 2018; 131:e56395-e56395.
Non-Responding Knee Pain with Osteoarthritis, Meniscus and Ligament Tears Treated with Ultrasound Guided Autologous, Micro-Fragmented and Minimally Manipulated Adipose Tissue
STRIANO, R.D., et al. Open Journal of Regenerative Medicine, 2017; 6:17-26.
Non-Responsive Knee Pain with Osteoarthritis and Concurrent Meniscal Disease Treated With Autologous Micro-Fragmented Adipose Tissue Under Continuous Ultrasound Guidance
STRIANO, R.D., et al. CellR4, 2015; 3(5):e1690.
Autologous and micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis
RUSSO, A., et al. Journal of Experimental Orthopaedics, 2017; 4:33.
The Effect of Intra-articular Injection of Autologous Microfragmented Fat Tissue on Proteoglycan Synthesis in Patients with Knee Osteoarthritis
HUDETZ, D., et al. Genes, 2017; 8(10):270.
Injection of autologous micro-fragmented adipose tissue for the treatment of post-traumatic degenerative lesion of knee cartilage: a case report
FRANCESCHINI, M., et al. CellR4, 2016; 4(1):e1768.
Micro Fractured and Purified Adipose Tissue Graft (Lipogems®) Can Improve the Orthognathic Surgery Outcomes Both Aesthetically and in Postoperative Healing
RAFFAINI, M., et al. CellR4, 2014; 2(4):e1118.
Microfractured Lipoaspirate May Help Oral Bone and Soft Tissue Regeneration: a Case Report
BENZI, R., et al. CellR4, 2015; 3(3):e1583.
Transnasal endoscopic microfractured fat injection in glottic insufficiency
SAIBENE, A. M., et al. B-ENT, 2015; 11(3):229-34.
Low back pain treated with disc decompression and autologous micro-fragmented adipose tissue: a case report
GROSSI, P., et al. CellR4, 2016; 1772:4.
Menopause: new frontiers in the treatment of urogenital atrophy
CASAROTTI, G.A., et al. European review for medical and pharmacological sciences, 2018; 22:567-574.
Autologous adipose tissue graft in the vulva in severe vulvar lichen sclerosus atrophicus: clinical case
DE VITA, D., et al. Italian Journal of Gynaecology & Obstetrics, 2016; 28(5).
Microfractured and Purified Adipose Tissue (Lipogems™ system) Injections for Treatment of Atrophic Vaginitis
FANTASIA, J., et al. The Journal of Urology, 2016, 3.7:1073.
Intersphincteric anal lipofilling with micro-fragmented fat tissue for the treatment of faecal incontinence: preliminary results of three patients
CESTARO, G., et al. Videosurgery and Other Miniinvasive Techniques, 2015; 10(2):337–341.
Recovery of Function in Anal Incontinence After Micro-Fragmented Fat Graft (Lipogems®) Injection: Two Years Follow Up of the First 5 Cases
GIORI, A., et al. CellR4, 2015; 3(2):e1544.
Micro‑fragmented adipose tissue injection for the treatment of complex anal fistula: a pilot study accessing safety and feasibility
NALDINI, G., et al. Techniques in coloproctology, 2018; 22(2):107-113.